OSU finds common cannabinoids block Sars-CoV-2 spike protein!

Big Sur

Well-known member
Now I will bet that the CDC, WHO and FDA will ignore this or claim that this research needs 20 more years of investigation. The US political leaders will press that you need a 12th booster jab for the 107th Covid-19 variant. Standard fare for many governments around the world and the health care industry as well as big pharma making trillions off of the virus. Like they are and have been ignoring other cheap effective preventatives like Vitamin D and Ivermectin. Several publications like the Boston Globe are already downplaying or doubting these published results.

However, the BIG NEWS is that here in Oregon, Oregon State University (OSU) has discovered that two Cannabis compounds: cannabigerolic acid, or CBGA, and cannabidiolic acid, CBDA, had the highest affinity for the spike protein and were confirmed to block infection by the virus. Yes, they block infection by the virus that is the current and persistent scourge of the earth: Sars-Covid-2, or Covid-19, the China Virus, Wahun Virus, Omicron, the Delta variant, etc. etc.

From OSU: https://today.oregonstate.edu/news/...unds-prevent-coronavirus-entering-human-cells

CORVALLIS, Ore. – Hemp compounds identified by Oregon State University research via a chemical screening technique invented at OSU show the ability to prevent the virus that causes COVID-19 from entering human cells.

Findings of the study led by Richard van Breemen, a researcher with Oregon State’s Global Hemp Innovation Center, College of Pharmacy and Linus Pauling Institute, were published today in the Journal of Natural Products.

Hemp, known scientifically as Cannabis sativa, is a source of fiber, food and animal feed, and multiple hemp extracts and compounds are added to cosmetics, body lotions, dietary supplements and food, van Breemen said.

Van Breemen and collaborators, including scientists at Oregon Health & Science University, found that a pair of cannabinoid acids bind to the SARS-CoV-2 spike protein, blocking a critical step in the process the virus uses to infect people.

The compounds are cannabigerolic acid, or CBGA, and cannabidiolic acid, CBDA, and the spike protein is the same drug target used in COVID-19 vaccines and antibody therapy. A drug target is any molecule critical to the process a disease follows, meaning its disruption can thwart infection or disease progression.

“These cannabinoid acids are abundant in hemp and in many hemp extracts,” van Breemen said. “They are not controlled substances like THC, the psychoactive ingredient in marijuana, and have a good safety profile in humans. And our research showed the hemp compounds were equally effective against variants of SARS-CoV-2, including variant B.1.1.7, which was first detected in the United Kingdom, and variant B.1.351, first detected in South Africa.”

Those two variants are also known the alpha and beta variant, respectively.

Characterized by crown-like protrusions on its outer surface, SARS-CoV-2 features RNA strands that encode its four main structural proteins – spike, envelope, membrane and nucleocapsid – as well as 16 nonstructural proteins and several “accessory” proteins, van Breemen said.

“Any part of the infection and replication cycle is a potential target for antiviral intervention, and the connection of the spike protein’s receptor binding domain to the human cell surface receptor ACE2 is a critical step in that cycle,” he said. “That means cell entry inhibitors, like the acids from hemp, could be used to prevent SARS-CoV-2 infection and also to shorten infections by preventing virus particles from infecting human cells. They bind to the spike proteins so those proteins can’t bind to the ACE2 enzyme, which is abundant on the outer membrane of endothelial cells in the lungs and other organs.”

Using compounds that block virus-receptor interaction has been helpful for patients with other viral infections, he notes, including HIV-1 and hepatitis.

Van Breemen, Ruth Muchiri of the College of Pharmacy and Linus Pauling Institute and five scientists from OHSU identified the two cannabinoid acids via a mass spectrometry-based screening technique invented in van Breemen’s laboratory. Van Breemen’s team screened a range of botanicals used as dietary supplements including red clover, wild yam, hops and three species of licorice.

An earlier paper in the Journal of the American Society for Mass Spectrometry described tailoring the novel method, affinity selection mass spectrometry, to finding drugs that would target the SARS-CoV-2 spike protein.

In the later research, lab tests showed that cannabigerolic acid and cannabidiolic acid prevented infection of human epithelial cells by the coronavirus spike protein and prevented entry of SARS-CoV-2 into cells.

“These compounds can be taken orally and have a long history of safe use in humans,” van Breemen said. “They have the potential to prevent as well as treat infection by SARS-CoV-2. CBDA and CBGA are produced by the hemp plant as precursors to CBD and CBG, which are familiar to many consumers. However, they are different from the acids and are not contained in hemp products.”

Van Breemen explains that affinity selection mass spectrometery, which he abbreviates to AS-MS, involves incubating a drug target like the SARS-CoV-2 spike protein with a mixture of possible ligands – things that might bind to it – such as a botanical extract, in this case hemp extract.

The ligand-receptor complexes are then filtered from the non-binding molecules using one of several methods.

“We identified several cannabinoid ligands and ranked them by affinity to the spike protein,” van Breemen said. “The two cannabinoids with the highest affinities for the spike protein were CBDA and CGBA, and they were confirmed to block infection.

“One of the primary concerns in the pandemic is the spread of variants, of which there are many, and B.1.1.7 and B.1.351 are among the most widespread and concerning,” he added. “These variants are well known for evading antibodies against early lineage SARS-CoV-2, which is obviously concerning given that current vaccination strategies rely on the early lineage spike protein as an antigen. Our data show CBDA and CBGA are effective against the two variants we looked at, and we hope that trend will extend to other existing and future variants.”

Van Breemen said resistant variants could still arise amid widespread use of cannabinoids but that the combination of vaccination and CBDA/CBGA treatment should make for a much more challenging environment for SARS-CoV-2.

“Our earlier research reported on the discovery of another compound, one from licorice, that binds to the spike protein too,” he said. “However, we did not test that compound, licochalcone A, for activity against the live virus yet. We need new funding for that.”

Timothy Bates, Jules Weinstein, Hans Leier, Scotland Farley and Fikadu Tafesse of OHSU also contributed to the cannabinoid study.





 

Jahnova

Well-known member
These variants are well known for evading antibodies against early lineage SARS-CoV-2,
This is not what the news has been telling us. It works wonders is the narrative. They're even trying to get people who went through the latest variant and have super updated antibodies to get their first Alfa shot. What a world....
 

Hanzde

Well-known member
my mother work in a Rehabcenter and no one I repeat no one have been tested positive for Covid in 2 years ,1 doctor have wrote a paper about it and it seams Kokain and Weed have some beneficial effect agains Covid yes and this is the proof now
 

Big Sur

Well-known member
If the Acid forms are effective then smoking cannabis wouldn’t be useful because the Acid forms would be converted to CBD/CBG.
That is true when curing and/or smoking weed. But not for drinking teas or infusions, or eating raw leaves. If you do not decarboxylize it, the acid forms stay in tact. Decarboxylation occurs at 230 degrees F. So boiling weed in water (212 F, or 100 C) ain't gonna convert the antivirals from CBDA or CBGA to CBD or CBG in your freshly harvested weed. CBD and CBG have their own benefits as well. Like anti-inflamatory and pain reduction.

Tea and salad anyone?
 

Big Sur

Well-known member
This is not what the news has been telling us. It works wonders is the narrative. They're even trying to get people who went through the latest variant and have super updated antibodies to get their first Alfa shot. What a world....
I take mega doses of Vitamin D and I also took preemptive (FLCCC doctor recommended) doses of Ivermectin until recently. I also had the J&J vax last year. Last August I had the Delta variant of Covid (only lost my sense of smell, no other symptoms). After that I stopped taking the Ivermectin. And they want me to get another booster... I said no. They screamed that I was putting people in harms way. I said I live alone, and acc'd to two doctors I have seen, the actual Covid virus worked as a booster and I do not need it. People howl when they hear that, claiming that I will wind up in the ICU if I do not get a booster RIGHT NOW! Never mind that the (which variant are we on now? oh yes, the omicron variant) has mild symptoms and not many are dying from it. It is also a super spreader virus, so EVERYONE will get it, symptoms or not. They also say I am taking way way way too much Vitamin D and that the Ivermectin would kill me. Zero problem taking either one. They are dirt cheap.

And yes, the news here is all about how you HAVE to get a booster, that Covid cases are through the roof, and everyone will need another booster or three every year from here to eternity.

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Deach69

Well-known member
I take mega doses of Vitamin D and I also took preemptive (FLCCC doctor recommended) doses of Ivermectin until recently. I also had the J&J vax last year. Last August I had the Delta variant of Covid (only lost my sense of smell, no other symptoms). After that I stopped taking the Ivermectin. And they want me to get another booster... I said no. They screamed that I was putting people in harms way. I said I live alone, and acc'd to two doctors I have seen, the actual Covid virus worked as a booster and I do not need it. People howl when they hear that, claiming that I will wind up in the ICU if I do not get a booster RIGHT NOW! Never mind that the (which variant are we on now? oh yes, the omicron variant) has mild symptoms and not many are dying from it. It is also a super spreader virus, so EVERYONE will get it, symptoms or not. They also say I am taking way way way too much Vitamin D and that the Ivermectin would kill me. Zero problem taking either one. They are dirt cheap.

And yes, the news here is all about how you HAVE to get a booster, that Covid cases are through the roof, and everyone will need another booster or three every year from here to eternity.

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Thanks for sharing Big Sur, it's nice to hear first hand experience with alternative methods of fighting COVID, and I like your point of view

Fk Kate Brown :poop:

🤙mu
@musashi , You mean the politician? Is she messing with the OSU research?
 

PlantManBee

Well-known member
That is true when curing and/or smoking weed. But not for drinking teas or infusions, or eating raw leaves. If you do not decarboxylize it, the acid forms stay in tact. Decarboxylation occurs at 230 degrees F. So boiling weed in water (212 F, or 100 C) ain't gonna convert the antivirals from CBDA or CBGA to CBD or CBG in your freshly harvested weed. CBD and CBG have their own benefits as well. Like anti-inflamatory and pain reduction.

Tea and salad anyone?
I respectfully disagree here. Decarboxylation will occur at lower temps but at a slower rate. Add to that the transfer of heat within a liquid is much greater than in a gas, PLUS the oxygen is being forced out of the water making it highly available for the process. Anecdotally I have used fresh weed simmered for two days in the crockpot that was actually mind-blowing.
 

Big Sur

Well-known member
Thanks for sharing Big Sur, it's nice to hear first hand experience with alternative methods of fighting COVID, and I like your point of view

@musashi , You mean the politician? Is she messing with the OSU research?
No problem. I have been booted off of other forums for sharing this Covid info, especially from the FLCCC (Ivermectin, Vitamin D, etc.). Also FB and IG and YT do not like anyone posting other than what the CDC party line is. Vax and more vax, then vax some more. Vax will become useless like antibiotics have. Now they are talking about annual boosters, like forever. That makes a lot of money for big pharma. And the pay for politicians to get elected.

As for Kate Brown, "it" is the governor of Oregon. "It" mandated vaccines for state employees and medical workers. Anyone that did not get the jab was fired w/o any unemployment benefits. "It" also only tows the CDC party line. So fuk "it". Of course that is my opinion, and not Mu's. "It" fortunately has no real control over the OSU research. I am sure that big pharma does not want the word getting out though. They have already gotten to publications like the Boston Globe to say things like "maybe" and "possibly" casting doubt on the research results. And they will see that any further results are buried as fast as possible. Or like they did with Ivermectin, pull the strings of some federal goon politicial comitee member from Michigan to bury the facts in DC when doctors and panels try to establish the validity of its use for Covid. Corruption is RAMPANT when it comes to Covid.
 
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